#5018 EFFECTS OF CANDESARTAN COMPARED TO LOSARTAN ON INHIBITING MESANGIAL EXPANSION IN DIABETIC MODEL RATS RECEIVING ROSMARINIC ACID

Abstract Background and Aims Oxidative stress activation of the renin-angiotensin system (RAS) due to chronic hyperglycemia are pathogenesis diabetic nephropathy (DN). Until now, therapy for DN has not shown satisfactory results. Rosmarinic acid (RA) which antioxidant, anti-inflammatory, anti-fibrosis effects, ARB can inhibit RAS may have a synergistic effect prevent progression. This study aims determine inhibiting mesangial expansion in rat models after being given combination RA (candesartan or losartan). Method True experimental laboratory trial with randomized post-test only control group method on Rattus norvegicus strain Wistar rats. Diabetic rats were prepared by giving high-fat diet (60% fat calories) single injection 40 mg/kg streptozotocin. Mice divided into 4 groups, each consisting rats: negative (healthy rats); positive (placebo that received candesartan; losartan. The glomerulus was evaluated assess using ImageJ 1.48 software 8 weeks treatment pathologist blindly. Data analysis One-way ANOVA Tukey's post hoc tests. Results results percentage matrix (81.49% ± 1.45) higher than (58.82% 0.99). + candesartan (61.56% 0.35) losartan (62.28% 0.77) showed lower group, test showing significant differences (p: 0.000). tests induced diabetes STZ significantly increased compared (MD: [22.66]; 95% CI: [20.62], [24.72]; p: inhibited [-19.92]; [-21.97], [-17.87]; 0.000), as well [-19.21]; 95%CI: [-21.26], [-17.16]; better but 0.735). Conclusion rosmarinic